Immunohistochemistry (IHC) Testing Services for Breast and Gynecological Cancer

Immunohistochemistry (IHC) analysis panels for breast cancer and gynecological cancers are an important aspect in early diagnosing, predictions, and staging of breast cancer and gynecological variants. Our IHC panels are the best line of defense for making predictive correlations between cancer biopsies and potential cancer blood markers.

    Advantages of IHC Testing

    • The cost of IHC panel testing is relatively low
    • Fresh or frozen tissue samples can be used for IHC
    • The risk to human health is low, due to no live infectious agent used
    • Increase clinical confidence
    • Invaluable tool because of its increased sensitivity when detecting antigens for diagnosing breast and gynecological cancers
    • The ability to determine tumor/cancer origins
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    About Tesis Labs immunohistochemistry (IHC) Testing for Breast and Gynecological Cancer

    What are some examples of immunohistochemistry stains we offer?

    There are hundreds of IHC panels available, the Cancer Subspecialty and Gynecological Subspecialty IHC panel stains are just a couple examples of what Tesis Labs can offer your medical practice.

    Cancer Subspeciality IHC Panel Stain

    Breast

    1. CK5/6 – Antibodies that target both cytokeratin 5 and
      cytokeratin 6.
    2. CKZ – Antibodies that target cytokeratin 7
    3. E-Cad – Transmembrane protein involved in cellular adhesion
    4. ER – For estrogen and progesterone receptors
    5. GCDFP-15 – Identify tumors of breast origin
    6. Her-2 – Human epidermal growth factor receptor
    7. Mammaglobin – A protein expressed in a majority of breast carcinomas
    8. P63 – Marker for striated muscle differentiation
    9. PR – For progesterone receptors
    10. SMM – An antibody to smooth muscle myosin

    Antibodies that target both cytokeratin 5 and cytokeratin 6. Antibodies that target Cytokeratin 7 Transmembrane protein involved in cellular adhesion For Estrogen and Progesterone Receptors Identify tumors of breast origin Human epidermal growth factor receptor.

    A protein expressed in a majority of breast carcinomas Marker for striated muscle differentiation For progesterone receptors An antibody to smooth muscle myosin.

    About Tesis Labs Immunohistochemistry (IHC) Testing for Breast and Gynecological Cancer

    Gynecological Subspeciality IHC Panel Stain

    Cervix, Vulva & Vagina

    1. CEA – Antigen (protein) present in very small quantities in adult tissue
    2. Ki-67 – Assess tumor cell proliferation in breast tissue embedded in paraffin
    3. P53  Surrogate for mutational analysis
    4. Vimentin – Differentiating soft tissue tumors
    5. Desmin – Detection of normal and neoplastic tissues

    Ovary

    1. AE1/3 – Antibody cocktail for generally positive cancers of epithelial origin
    2. CD30 – Antigen important in diagnosis of classic Hodgkin’s lymphoma
    3. EMA – Useful in labeling cells of lymphoid origin
    4. Reticulin – Demonstrates silver fibers around groups of granulosa cells

    Endometrium

    1. EMA – Useful in labeling cells of lymphoid origin
    2. ER – For estrogen and progesterone receptors
    3. P53 – Surrogate for mutational analysis

    Mesenchymal

    1. CD10 – Marker of normal endometrial stroma
    2. Cyclin DI – Distinguishes mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow
    3. HMB4 – Distinguish benign from malignant melanocytic tumors
    4. Mart-1 – Recognize cells of melanocytic differentiation
    5. SMA – Detection of specific antigens of interest in normal and neoplastic tissues

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